Scientists obtained substances that provide a breakthrough in the treatment
of neurodegenerative pathologies.
Russian scientists have synthesized chemical compounds that can stop the
degeneration of neurons in Alzheimer’s, Parkinson’s, and other severe brain
pathologies. These substances can provide a breakthrough in the treatment of
neurodegenerative pathologies.
New molecules of pyrrolyl- and indolylazine classes activate intracellular
mechanisms to combat one of the main causes of “aged” brain diseases – an
excess of so-called amyloid structures that accumulate in the human brain
with age. The essence of the study was published in the European Journal of
Medicinal Chemistry. Experts from the Institute of Cytology of the Russian
Academy of Sciences, the Institute of Organic Synthesis of the Ural Branch
of the Russian Academy of Sciences, and the Ural Federal University (UrFU)
took part in the study.
“Our compounds activate the synthesis of specific heat shock proteins and
cause their accumulation in the cell,” said research co-author, professor of
the Department of Organic and Biomolecular Chemistry at UrFU Irina Utepova.
“Proteins of this type make it possible to protect neuronal tissue from an
excess of toxic amyloids and to protect cells from various types of stress,
including proteotoxic stress characteristic of neurodegenerative diseases.”
Important advantages of compounds from the series of pyrrolyl- and
indolylazine classes are a profitable synthesis technology and low toxicity.
The obtained compounds were tested in cellular models of Alzheimer’s disease
and secondary injuries after traumatic brain injury. In both cases, the new
substances demonstrated a significant therapeutic effect, increasing the
survival of neuronal cells. The most effective compound has been tested in
living tissues of rats with secondary injuries after traumatic brain injury.
According to scientists, the use of pyrrolylazine in rehabilitation therapy
allowed the animals to avoid the appearance of movement disorders and
degeneration of hippocampal neurons. The research team has been continued to
study the mechanism of action of new compounds and is preparing for their
preclinical testing.
Note
Alzheimer’s and Parkinson’s diseases are diseases of the brain, in which
gradual degeneration of neurons leads to loss of speech, memory, and
thinking. Most often they affect people over 65 years old. The global number
of people suffering from Alzheimer’s disease alone in 2010 was estimated at
35.6 million. By 2050, growth is projected to 115.4 million. Effective drugs
for the prevention and treatment of ailments of this type have not yet been
created. Existing remedies are aimed only at suppressing symptoms, but
cannot stop the process of neurodegeneration itself.
Reference:
Synthesis and approbation of new neuroprotective chemicals of pyrrolyl- and
indolylazine classes in a cell model of Alzheimer’s disease” by Elizaveta A.
Dutysheva, Irina A. Utepova, Maria A. Trestsova, Alexander S. Anisimov,
Valery N. Charushin, Oleg N. Chupakhin, Boris A. Margulis, Irina V. Guzhova
and Vladimir F. Lazarev, 26 May 2021, European Journal of Medicinal
Chemistry.
My sister is 61 years old and has been suffering from PD for the past 6years. Lately her condition started hallucinating and I did not know how to handle the situation. She could not sleep and tried to find and catch the imaginary people who she thinks are real, she had tremors for several years and was gradually becoming worse before we found PD herbal supplement from www .multivitamincare. org that was able to get rid of her disease and alleviate all symptoms within the short period of her 15 weeks of usage.
ReplyDelete