Researchers Discover New Stem Cells That Can Generate New Bone

Many areas of the body are home to niches of stem cells that differentiate into tissue progenitors. For several years, biologists have known that bone stem cells are present in two particular places: bone marrow and periosteum. Previous research has also shown that there are vascular channels for cell transfer between the bone marrow and the outside of the bone. And recently, scientists have discovered that these channels themselves harbor bone progenitor stem cells.

A population of stem cells with the ability to generate new bone has been newly discovered by a group of researchers at the UConn School of Dental Medicine.

In the journal STEM CELLS, lead investigator Dr. Ivo Kalajzic, professor of reconstructive sciences, postdoctoral fellows Dr. Sierra Root and Dr. Natalie Wee, and collaborators at Harvard, Maine Medical Research Center, and the University of Auckland present a new population of cells that reside along the vascular channels that stretch across the bone and connect the inner and outer parts of the bone.

“This is a new discovery of perivascular cells residing within the bone itself that can generate new bone forming cells,” said Kalajzic. “These cells likely regulate bone formation or participate in bone mass maintenance and repair.”

Stem cells present in the intraosseous canals

Stem cells for bone have long been thought to be present within bone marrow and the outer surface of bone, serving as reserve cells that constantly generate new bone or participate in bone repair. Recent studies have described the existence of a network of vascular channels that helped distribute blood cells out of the bone marrow, but no research has proved the existence of cells within these channels that have the ability to form new bones.

In the intraosseous vascular channels, in addition to the immune and bone blood cells, the researchers discovered bone stem cells capable of repairing the structure. Credits: Christopher Ritchlin & Iannis E. Adamopoulos

In this study, Kalajzic and his team are the first to report the existence of these progenitor cells within cortical bone that can generate new bone-forming cells – osteoblasts – that can be used to help remodel a bone.

To reach this conclusion, the researchers observed the stem cells within an ex vivo bone transplantation model. These cells migrated out of the transplant, and began to reconstruct the bone marrow cavity and form new bone.

While this study shows there is a population of cells that can help aid bone formation, more research needs to be done to determine the cells’ potential to regulate bone formation and resorption.

This study was funded by the Regenerative Medicine Research Fund (RMRF; 16-RMB-UCHC-10) by CT Innovations and by National Institute of Arthritis and Musculoskeletal and Skin.


Perivascular osteoprogenitors are associated with transcortical channels of long bones.

Sierra H. Root, Natalie K. Y. Wee, Sanja Novak, Clifford J. Rosen, Roland Baron, Brya G. Matthews, Ivo Kalajzic.


DOI: 10.1002/stem.3159


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